Peptide Library Services

AI-Guided Peptide Library Design Platform

Design from scratch, rapidly and with high precision.

GenScript is combining its industry-leading peptide synthesis and library design capabilities with advanced machine learning technology/platform to create a cutting-edge solution that accelerates peptide-based therapeutic development.

Central to this approach is an automated platform that streamlines drug design by rapidly generating biomolecules with optimized developability and precise target binding. By integrating this technology with validated synthesis workflows, the solution enhances success rates in early-stage discovery, reduces experimental costs, and shortens development timelines — all achievable in a matter of days.

Case Study

• Glucagon-like peptide-1 (GLP-1) Receptor Agonist
  

  14 of the tested peptides showed biological activity, with 3 exhibiting single-digit nanomolar potency – performance typically achieved only after multiple design iterations.

  Rapid Peptide Discovery for GLP-1R by using Generative Biologics engine

  Designed 5,000+ novel candidates in 72 hours — enabling rapid screening without iterative cycles.

  Based on predicted affinity scores and binding energy calculations, 20 top candidates were synthesized and evaluated, revealing 14 biologically active peptides—including 3 with exceptional single-digit nanomolar potency— typically requiring multiple design cycles to achieve.

  At GenScript, our AI-guided library design platform leverages this approach to help you design and deploy custom peptide libraries from scratch, rapidly and with high precision. Whether you’re targeting receptor families (e.g., GLP-1R), immuno-targets or proteomics, we stand ready to turn advanced algorithms into tangible screening assets.

  *Collaborating with Insilico Medicine — a global leader in AI for biotechnology.

Design

GenScript provides six free online peptide library design tools to ensure you create the library that best fits your research needs:

Overlapping
peptide library

Alanine
scanning

Positional
scanning library

Truncation
library

T-cell
truncated library

Random
library

Scrambled
library

Custom Peptide Pools

Fast, pooling of immunostimulant peptides LC-MS marker peptide validation 2 flexible packages Read more >>

Select your Peptide Libraries by applications

Check out our peptide library design guide to get detailed instructions on how to pick the right Peptide Libraries for your research:

Applications	Service	Design	Purity
T-cell Immunotherapy	Micro-scale Peptide Library or Standard Peptide Library	Overlapping Library and Truncated Library	Crude or ≥70%
Vaccine Development	Standard Peptide Library	Overlapping Library or Alanine Scanning Library	High Purity (≥90%)
Cancer Research	Standard Peptide Library	Overlapping Library	Crude or ≥70%
Antibody and T-cell Epitope Mapping	Standard Peptide Library	Overlapping Library, Positioning Scanning Library or Truncated Library	Crude or ≥70%
Proteomics	Micro-scale Peptide Library	Overlapping Library	Crude
Biological Assays	Micro-scale Peptide Library or Standard Peptide Library	Overlapping Library or Scrambled Peptide Library	≥70% or higher

FAQs

• How do you handle complex sequences for peptide library to ensure successful delivery?

  Some sequences in your peptide library may present synthesis challenges that could impact overall delivery timelines. To ensure smooth progress, we’ll proactively keep you informed throughout production — and we highly recommend the following strategies:

  • Pilot-Scale Test Run (<97 sequences to validate feasibility)
  • Staggered Synthesis (Split large libraries into smaller sub-libraries to reduce risk)
  • Simplified Modifications (e.g., use acetylation instead of complex labels where possible)

  Our goal is to deliver your full library successfully — we’re here to help you choose the smartest path forward.

• What are the applications of peptide libraries?

  Peptide library is a systematic combination of different peptides in large number. It is widely used in drug screening, target validation, epitope mapping, vaccine development, and structure-activity studies.

• Can Genscript provide peptide library design tool?

  Yes, GenScript can provide free design tool for peptide library using the link below,
  https://www.genscript.com/peptide_screening_tools.html

• How to design a peptide library?

  Peptide libraries are systematic combinations of a large variety of peptides, which are widely used for target screening in popular research areas such as immunotherapy, vaccine development, drug discovery and proteomics. By simultaneously screening hundreds of peptide combinations to identify important bioactive peptides, selecting the right peptide library design can ensure that your research progresses smoothly, the recommendations for different researches are shown in the table below.

  GenScript can provide multiple tools for peptide library design, please kindly find the link below:
  https://www.genscript.com/peptide_screening_tools.html

• How GenScript synthesize peptide library?

  Most GenScript's peptide libraries are synthesized with the proprietary PepHTS™ platform, some difficult sequences are synthesized via semi-automatic synthesizer

• What type of library do you provide?

  GenScript provides several types of peptide library, including standard peptide library, crude peptide library, purified peptide library and micro-scale peptide library.

• Can you provide purified micro-scale peptide library? What's the purity?

  Yes, GenScript able to provide purified micro-scale peptide library with guaranteed purity > 70%.

• What customization options are available for peptide libraries?

  Researchers can customize their peptide libraries by specifying the peptide length, amino acid sequences, modifications, and quantity. GenScript also offers consultation services to assist with designing the optimal peptide library for specific research needs.

• What is the turnaround time for peptide library synthesis?

  The turnaround time for peptide library synthesis varies depending on the complexity and size of the library. GenScript provides estimated delivery timelines based on the specific requirements of each project.

• What are the different synthesis scales available for peptide library production through GenScript?

  GenScript offers a range of synthesis scales for peptide library production, including milligram to gram-scale synthesis, to accommodate different research needs and applications.

• Can GenScript accommodate specific purity requirements for peptides within a library?

  Yes, GenScript can accommodate specific purity requirements for peptides within a library, with options for crude, high purity (>70%) and ultra-high purity (>98%) available.

• Are there any specific bioconjugation or labeling options available for peptides within the library?

  GenScript provides bioconjugation and labeling options for peptides within the library, including fluorescent dyes, biotin, and other custom labeling or modification services as needed.

• Are there any case studies or examples available showcasing the successful use of GenScript's peptide library service in research or industry applications?

  Yes, GenScript provides case studies and examples showcasing the successful use of its peptide library service in various research and industry applications, demonstrating the impact and versatility of the synthesized libraries. The case studies are available on peptide resources on GenScript's webpage.

• Any modification type included in peptide library?

  GenScript's peptide library service contains the basic peptide preparation, modified peptide, cyclic peptide etc. Feel free to contact our professional sales team to know more.

• Can you help me to pool my peptide after peptide library synthesis?

  As a complement to our peptide library service, GenScript can prepare customized peptide pools according to your customized specifications with pre-pooling LC-MS validation, and post-pooling marker validation QC options.

• What's the package available for peptide pooling?

  You can choose from 2 flexible package options:

  Package	Deliverables
  PepPool Standard	COA, MS, and HPLC validation data for each peptide before pooling Lyophilized pool(s) delivered 96-well plate or 100-tube rack Free aliquoting (up to 10 vials)
  PepPool Plus	COA, MS, and HPLC validation data for each peptide before pooling LC-MS on marker peptides (up to 8) in final pool to guarantee presence of all peptides within the final pool Lyophilized peptides in specified pool(s) delivered in a 96-well plate or 100-tube rack Free aliquoting (up to 10 vials)

  Note:*Single non-pooled peptides can be supplied upon request.

Technology and Quality

Peptide libraries are synthesized using our proprietary PepHTS™ Peptide Library technology and undergo vigorous quality control to avoid cross-contamination prior to delivery. Click here to find out more about our Total Quality Management System.